Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit:

a Precision Medicine Approach

Plug values from the time point when severe acute kidney injury occurs* (KDIGO III or RIFLE failure stage).



*Provided the patient meets inclusion/exclusion criterion for the AKIKI or IDEAL-ICU trials.

RRT = Renal-Replacement Therapy; CI = Confidence Interval; HR = Hazard Ratio; ARR = Absolute Risk Reduction.


References

Gaudry S, Hajage D, Schortgen F, Martin-Lefevre L, Pons B, Boulet E, et al. Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit. New England Journal of Medicine. 2016 Jul 14;375(2):122–33.

Barbar SD, Clere-Jehl R, Bourredjem A, Hernu R, Montini F, Bruyère R, et al. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis. New England Journal of Medicine. 2018 Oct 11;379(15):1431–42.


Contact: François Grolleau francois.grolleau@aphp.fr
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